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Ancient Sanskrit texts like the Mahabharata, the Ramayana, as well as the Puranas explain the nagas as a powerful, splendid and proud semi-divine species that may assume their Actual physical type possibly as human (generally using a halo of cobra hoods driving their head), being a partially human serpent, or as a whole serpent. Their domain is inside the enchanted underworld, the underground realm filled with gems, gold along with other earthly treasures called Naga-loka or Patala-loka. They're also frequently associated with bodies of waters — including rivers, lakes, seas, and wells — and are guardians of treasure.[ten] Their energy and venom make them probably perilous to human beings. However, in Hindu mythology, they often take the position of benevolent protagonists; during the Samudra Manthana, Vasuki, a nagaraja who abides on Shiva's neck, became the churning rope for churning in the Ocean of Milk.
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You will find a Tale of the naga who appeared in human type making sure that he could become a Buddhist monk. The Buddha advised him that only human beings were being allowed to turn into monks. The naga took the 5 precepts to ensure that he could be reborn being a human inside a upcoming existence.[9]
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The precise purpose from the metal cofactor is of individual curiosity for NagA because the two crystal constructions accessible for the enzyme from E. coli
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utilizes just one metal certain completely into the β-website. Quite possibly the most Extraordinary case in point in the amidohydrolase superfamily is uronate isomerase from E. coli
Mutation of Y223 into a phenylalanine residue resulted in the mutant with just about the identical catalytic exercise given that the wild form enzyme and so this residue is not really major for that binding of substrate in NagA.
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